N4-amino-acid derivatives of 6-azacytidine: structure-activity relationship.

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N4-amino-acid derivatives of 6-azacytidine: structure-activity relationship.

Several N4-derivatives of 6-azacytidine were synthesized using of Vorbrüggen's condensation method. Their antiviral activity with respect to the adenovirus serotypes 2 and 5 in Hep-2 cells culture was studied and primary specific activity was determined. Correlation between chemical structure of new 6-azacytidine derivatives and their biological properties is discussed.

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ژورنال

عنوان ژورنال: Acta Biochimica Polonica

سال: 2000

ISSN: 1734-154X,0001-527X

DOI: 10.18388/abp.2000_4066